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Year : 2019  |  Volume : 8  |  Issue : 3  |  Page : 153-158

Cathepsins in oral diseases

1 Department of Oral Pathology, Drs. Sudha and Nageswara Rao Siddhartha Institute of Dental Sciences, Gannavaram, Andhra Pradesh, India
2 Department of Oral Pathology, GSL Dental College and Hospital, Rajahmundry, Andhra Pradesh, India
3 Department of Oral Pathology, Panineeya Dental College, Hyderabad, Telangana, India
4 Department of Oral Pathology, Navodaya Dental College, Raichur, Karnataka, India

Correspondence Address:
Dr. K Roja Lakshmi
Department of Oral Pathology, GSL Dental College and Hospital, Rajahmundry, Andhra Pradesh
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Source of Support: None, Conflict of Interest: None


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Cathepsins are a class of globular lysosomal proteases known to be responsible for protein degradation. In addition to proteolysis they have many biological roles such as apoptosis wound healing angiogenesis, proenzymatic activation, bone remodelling and resorption. Cathepsins role has been implicated in the pathogenesis of systemic diseases such as cancer, bronchial asthma, atherosclerosis, neurological disorders, rheumatoid arthritis and osteoarthritis. This review highlights the role of cathepsins in various oral diseases like periodontitis, odontogenic cysts, ameloblastomas, salivary gland tumours and oral malignant melanoma.

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