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Year : 2021  |  Volume : 10  |  Issue : 2  |  Page : 109-111

Reversible cutaneous pigmentation due to deficiency of vitamin B12

Department of Medicine, Sarojini Naidu Medical College, Agra, Uttar Pradesh, India

Correspondence Address:
Ms. Boentika Singh
Department of Medicine, Sarojini Naidu Medical College, Agra, Uttar Pradesh
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Vitamin B12 deficiency is rare and presents with combinations of hematological changes, discoloration of skin, hair and nails, weakness, syncope, and diarrhea. Causes of vitamin B12 deficiencies are malabsorption, pernicious anemia, gastric resection, and rarely inadequate intake. Inadequate intake occurs commonly in people having a strict vegetarian diet. Megaloblastic anemia has a slow onset when compared to that of other anemias. It results in defect in the red cell DNA synthesis and is mostly due to hypovitaminosis, specifically vitamin B12 deficiency. Hyperpigmentation of skin has been reported in medical literature as the presenting manifestation of vitamin B12 deficiency.

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