Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
Print this page Email this page Users Online: 116
REVIEW ARTICLE
Year : 2021  |  Volume : 10  |  Issue : 2  |  Page : 69-71

Abametapir: A novel pediculicide with a unique mechanism


1 Department and Institution-Senior Lecturer, Department of Pharmacology, Dr Harvansh Singh Judge Institute of Dental Sciences, Panjab University, Sector 25, Chandigarh, India
2 Department and Institution-Consultant Cardiologist, Heartline, SCO 60, Sector 6, Panchkula, Haryana, India

Correspondence Address:
Dr. Suruchi Aditya
Department of Pharmacology, Dr Harvansh Singh Judge Institute of Dental Sciences, Panjab University, Sector 25, Chandigarh
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jdrntruhs.jdrntruhs_151_20

Rights and Permissions

Pediculus humanus capitis or head louse, a blood-sucking, wingless arthropod, has been a source of repulsion and embarrassment causing social distress, parental anxiety, and absenteeism. The battle to eradicate this infestation has not been rewarding as the obligate parasite continues to produce resistance to effective first-line pediculicides such as permethrin. Abametapir is a new pediculicide that inhibits the metalloproteinases critical to the hatching process of the eggs. Being an ovicidal drug, it needs a single application. In two large phase 3 studies with 704 subjects aged ≥6 months, abametapir lotion eliminated lice in ≥80% of subjects after a single 10-min application with no nit combing. The common adverse effects observed are erythema, rash, and sensation of skin burning. The Food and Drug Administration approved abametapir lotion, 0.74%, for a one-time topical treatment of head louse infestation for patients aged 6 months and older in July 2020. Good efficacy, safety, and a novel mechanism of action make it a welcome addition to the list of effective lousicidal drugs.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed359    
    Printed12    
    Emailed0    
    PDF Downloaded48    
    Comments [Add]    

Recommend this journal